Singer Christina Grimmie, who had competed on the US TV programme The Voice, has died of her wounds after being shot in Florida, police say.
The assailant - who was tackled by Ms Grimmie's brother - then shot and killed himself. The 22-year-old singer died in a local hospital.
In 2014, Ms Grimmie finished third during season six of The Voice.
In a tweet, Orlando's police wrote: "With deep regret, we have confirmed Christina Grimmie, @TheRealGrimmie has died from her injuries."
Meanwhile, Ms Grimmie's publicist said: "It is with a heavy heart that we can confirm that Christina has passed and went home to be with the Lord."
Police say Ms Grimmie was shot about 22:45 local time on Friday (02:45 GMT Saturday) at The Plaza Live in Orlando.
The gunman opened fire as she was signing autographs for fans with Before You Exit band.
The attacker, whose name has not been released, had two guns.
Orlando Police Department spokeswoman Wanda Miglio said Grimmie's brother "immediately tackled the suspect".
"During the struggle, the suspect shot himself. The suspect was pronounced dead at the scene," the spokeswoman said.
She described Ms Grimmie's brother as a "hero" for stopping the attacker "from not hurting anyone else".
A police investigation is now under way into how the suspect had managed to enter the venue with the firearms.
News of the attack spread quickly on social media, with many fans voicing their shock and anger.
Ms Grimmie first came to prominence as a teenager for her renditions of hit songs, amassing a huge following on YouTube.
In 2011, she released her debut musical recording Find Me. Her second EP - Side A - followed in February 2016.
In her last tweet on Friday, she wrote:
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